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DRUG RELEASE - Coggle Diagram

- - - - applicable for sustained released dosage form
      - applicable to some transdermal systems as well as matrix tablets with low soluble drugs in coated forms, ormotic systems
  - - - applicable to immediate release
      - applicable to those containing water-soluble drugs in porous matrices
  - - - suitable for simpler systems where diffusion is the primary mechanism such as topical creams or transdermal patches
      - applicable to matrix tablets with water soluble drugs
  - - - suitable for systems where the release involves multiple processes such as diffusion, swelling, and erosion
    - - you have the freedom modify the release
- - - - describes the flux of particles across a unit area due to a conc gradient
      - steady state conc gradient
      - proceeds to low: assume that all molecules do not diffuse out of a system
    - - describes how particles changes with both time and space
        
        the change in concentration in a particular place with time is proportinal to the change in concentration gradient at that particular place in the system
      - non-steady state conc gradient
      - time dependent
    - - rate of dissolution of a solid is depending upon its solubility, the conc of solute in solution at a particular time, diffusivity, and the surface area of the solid
      - diffusion later: stagnant layer
- - - - rapidly dissolving
        
        = 85% of the API is released from the comparator and test drugs within 30 minutes
      - very rapidly dissolving
        
        = 85% of the API is released from the comparator and test drugs within 15 minutes
  - - - designed to pass through the stomach unaltered, later to release their medication within the intestinal tract
      - enteric coated
    - - designed to release their medication in a controlled manner, at a predetermined rate, duration, and location to achieve and maintain optimum therapeutic blood levels
      - hydrophilic cellulose polymers: commonly used as the excipient base in tablet matrix systems
        
        the effectiveness is based on the successive processes of hydration, gel formation, tablet erosion, and the subsequent and continuous release of drug
        
        any adjuvant that can alter water uptake rate, swelling, and gelling characteristics of martrixing agents can alter the release rate of API
        
        alkaline polymers can increase drug release of acidic drugs