BL clinic: consent, questionnaires, renal function (if necessary for hospital policy), heart rate, BP, oxygen saturation, lung function (if not done within 6 weeks), 1 min sit to stand test, or 6 min walk test where appropriate. Low-dose CT and Xenon MRI at BL (if CT not done within 6 weeks) at Oxford and Sheffield.
Sheffield responsible for standardised imaging protocol and central analysis of MRI data. Pts from Cardiff/Manchester travel to Sheffield or Oxford.
FU visit: up to 2, depending on outcome of BL. If abnormality on BL Xenon MRI, invited to repeat assessments at visit 2. If visit 2 Xenon MRI detects further abnormalities visit 3 offered to repeat assessments. If no abnormalities at BL found: Qaires electronically completed at 3-12 months post-BL only.