Please enable JavaScript.
Coggle requires JavaScript to display documents.
Mechanism and benefits of inflammation - Coggle Diagram
Mechanism and benefits of inflammation
Mechanism
Smooth muscles
around larger blood vessels
contract to slow the flow of blood
through the capillary beds at the infected or injured site
Importance
Give
more opportunity for leukocytes
to
adhere
to the wall of capillary and
squeeze out into the surrounding tissue
The
endothelial cells
that make up the wall of the smaller blood vessels
contract
Importance
vasodilation occurs. The space between the endothelial cells increases --> increased
capillary permeability
Benefits
Plasma flows out
of the blood into tissue
proteins of the complement pathways
entering the tissue to help
remove microbes
Clotting factors
entering the tissue causing
fibrin clots to form
Antibody molecules
entering the tissue to help to remove or
block the action of microbes
Adhesion molecules are activated
on the surface of the endothelial cells on the inner wall of the capillaries
Results
Corresponding molecules called
integrins
on the surface of leukocytes
attach to these adhesion molecules
Benefits
Diapedesis occurs.
Leukocytes flatten
and
squeeze through
the space between the endothelial cells and enter tissue
increase
phagocytosis
increased
inflammation
Immune
killing
of infected cells and cancer cells; production of
cytokines