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Chapter 26: Gastrointestinal regulation - Coggle Diagram
Chapter 26: Gastrointestinal regulation
3 regulators
endocrine
paracrine
gastrin family
gastrin
CCK
secretin family
secretin
glucagon
glicentin
VIP
GIP
enteroendocrine cells 15 types
extrinsic innervation- enteric NS
Gastrin
g-cells in antrum
flask shaped, base containing gastrin granules
stimulation of gastric acid and pepsin secretion
growth of mucosa (trophic action)
phenylalanine and tryptophan increase secretion
Cholecystokinin
mucosa of upper small intestine
stim panc enz
contraction of gallbladder
relax sphincter of oddi
inh gastric emptying
trophic effect on pancrease
enetrokinase synt
contraction of pyloric sphincter
stimulates glucagon secretion
p445
Secretin
S cells in the upper portion of small intestine
increases bicarb in duct of pancreas and biliary tract
acid stimulates secretion
causes alkaline fluid to go in lumen
VIP
secretion of electrolytes into intestine
relax SM
in same neurons as Ach
SOmatostatin
Gh inhibit
inh gastrin, VIP, GIP, secretin and motilin
stimulated by acid in lumne
inh pancreatic exocrine secretion, gastric secretion, motility and gall bladder contraction
Motilin
erythromycin binds to motlin receptors
increase gut motility
Other Peptides
Peptide YY
inh gastric acid and motility
Others
Ghrelin
food intake
Substance P
increases motility in small intestine
GRP
increase gastrin secretion
Guanylin
Cl- secretion in lumen
ecoli as structure that activate these receptors
Enteric nervous system
Myenteric plexus
SM layer
submucous plexus
neurotransmitters
Ach
serotonin
nor-epi
GABA
ATP, NO, CO
Extrinsic innervation
GIT circulation
Splanchnic circ - parallel supply