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Biopharmaceutical Classification System (BCS) - Coggle Diagram

- - - - 1.4 - 2.1 - stomach
      - 4.9 -6.4 - duodenum
      - 4.4 - 6.6 - jejunum
      - 6.5 - 7.4 - ileum
        
        take 85 min for a drug to reach ileum
        
        by the time it reaches ileum, the dissolution of the drug is likely complete if it meets the rapid dissolution criterion, i.e., no less than 85% dissolved within 30 mins
- - - - the shortest time needed for reaching the plateau of drug concentration against time could be considered equillibration time
  - - - stir for until the equilibration time
        
        filter
        
        measure conc of API
        
        dose solubility ratio
        
        highest single therapeutic dose (mg)/least equilibrium solubility (mg/mL)
        
        to remove undissolved API
        
        sonication, beads, agitation to prevent agglomeration and poor wettability
      - measure the pH
    - - mechanical agitation at 37 +/- 1 C
      - method that estimates the solubility of ionizable drug-like molecules at equilibrium as a function of pH
      - recommended by the WHO
    - - 1.2 - stomach
      - 4.5 jejunum
      - 6.8 ileum
      - need to measure the solubility of drug at its pKa
    - - pH solubility profile
      - solubility of salts
      - potentiometric titration
      - turbidimetry
      - miniaturization, high-throughput and automation in solubility management
- - - - to reduce the risk of bioinequivalence to an acceptable level