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Dermato, BCC VS SCC, 🐥 2 images, 350, Diagram - Coggle Diagram
Dermato
Lichen Planus
5 "Ps": pruritic, purple/pink, polygonal, papules & plaques
Lacy, white network of lines (Wickham striae)
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risk may be increased
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taking certain medications (eg, ACE inhibitors, thiazide diuretics)
gradual, spontaneous remission within 2 years.
Biopsy
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Thickened stratum granulosum, [ saw tooth appearance ]
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Epidermolysis bullosa
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EB simplex, is caused by mutations in keratin genes that impair the assembly of keratin into filaments.
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ichthyosis vulgaris
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accumulation of dry, scaly skin with loss of normal barrier function.
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Erythema multiforme
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acute, inflammatory skin disorder that usually develops in the setting of an ongoing infection.
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cause
deposition of infectious antigens in keratinocytes, leading to a strong cell-mediated (eg, cytotoxic T-cell) immune response.
Actinic keratoses (AKs) keratinocyte atypia, hyperkeratosis, and parakeratosis.
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small, scaly, erythematous lesions They are often "felt more than seen" and have a rough, sandpaper-like texture on palpationoccurring on sun-exposed areas.
Seborrheic Keratoses
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has a variable appearance from nearly flat macules to raised, wart-like lesions,
etiology
not fully understood; however, it is frequently associated with activating mutations of the fibroblast growth factor receptor 3.
benign, but rapid onset of numerous SKs (Leser-Trélat sign) is often associated with an internal malignancy (eg, gastric adenocarcinoma), possibly due to overproduction of insulin-like growth factor 1 and other cytokines.
hidradenitis suppurativa
painful, deep-seated nodules and scar formation in the axillae, groin, and medial thighs.
pathogenesis
hyperproliferation and abnormal keratinocyte differentiation --> occlusion of folliculopilosebaceous units
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Dermatitis herpetiformis
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Biopsy
The overlying basal cells become vacuolated, and blisters form at the tips of the involved papillae.
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Psoriasis
Biopsy
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dilated capillaries in the dermal papillae, and foci of neutrophils in the superficial epidermis.
BCC VS SCC
biopsy
nests of dysplastic keratinocytes which often have abundant cytoplasm that appears eosinophilic due to keratin filaments. Keratin pearls (also eosinophilic) are commonly present.
nests of basaloid cells that appear dark blue due to their basophilic, hyperchromatic nuclei and scant cytoplasm.
Cells at the periphery frequently display parallel alignment (ie, peripheral palisading)
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classically has a translucent or pearly appearance,
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