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Amyloid-Lowering Agents - Coggle Diagram
Amyloid-Lowering Agents
Monoclonal Antibodies
Aducanumab
binds to aggregated AB
Lecanemab
binds to amyloid fibrils
(prevents aggregation)
BACE1 Inhibitors
Prevents cleaving of APP
Gamma-secretase Inhibitors
Immunotherapy
Active immunisation
vaccines
Passive immunisation
exogenous antibodies
Aggregation Inhibitors
prevent monomers from becoming oligomers
Limitations
Efficacy challenges
(especially in late-stage AD)
ARIA
(edema/hemorrhages in MRI)
intervention must be early
Expensive
References
Cummings 2023