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HRT (Estrogen and Progesterone) - Coggle Diagram
HRT
(Estrogen and Progesterone)
Regulates
Apoptosis
AB Production/Clearance
Increases
Neuronal Growth (+BDNF)
Acetylcholine (+Choline acetyletransferase)
Synaptic Plasticity
Dendretic spine density
Energy metabolism (+ Mitochondrial function)
Decreases
Oxidative stress
Inflammatory cytokines
Tau hyperphosphorylation (WNT pathway)
Example Drugs
Estradiol
References
Wharton et al. 2011
Limitations
Start time
(Critical window = menopause)
Not approved for AD
(just menopause)
Long-term HRT:
breast cancer
stroke
thromboembolism
Not effective in advanced AD