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Host Pathogen Interaction - Coggle Diagram
Host Pathogen Interaction
Relationship between microbes & humans
Symbiotic Relationships
Mutalisim (+/+)
Bacteria in colon
Benefit to human
1) Metabolisation undigested carbs & provide additional nutrients
2) 🛡️ of colon from colonization & infection from pathogens
3) Stimulation of immune system
4) Breakdown waste
Benefit to bacterium
Assured food supply 🍲& sheltered environment ⛺
Commensalism (+/0)
Oral microbiota
Microbiota benefit from the food source (specifically sugars). While humans= no adv or disadv
Parasitisim (+/-)
Host provides the parasite with their physicochemical environment, food, respiratory & other metabolic needs.
How it could occur:
dysbiosis
can lead to disease and some bacteria becoming parasites
Relationship between microbiota & humans
1) Gut-brain axis (GBA), where it can strimulate immune response.
2) Increased range of metabolic processing
3) Physical barrier --> protection against exogenous pathogen by competing for nutrients, occupying space & producing antimicrobial substances
Microbiota: location & role
Skin
it has various microbes cause it has different levels of oxygen, moist, acidity and salt depending on the location. The most moist area would contain most of microbes.
Mouth
: different bacteria including anaerobe. Entry point for bacteria to colonise URT.
Saliva contains both nutrients but antibacterial substances like lysozymes
Respiratory tract
: divides into upper & lower
Upper: microbiota in: nose, nasal cavity & nasopharynx, throat(oropharynx and larynx)
Lower: Trachea, primary bronchi (gas exchange), microorganisms removed by mucus.
Stomach
Hostile environment for bacteria, acidic pH (2.0), gastric mucosa.
Intestine
Small: Microbial numbers increases here past stomach.
Large: Dense with the larger number of bacteria, many bacteria (app. 95-99%) are anaerobic due to the lack of oxygen.
