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Anti-neoplastic agents (Anti-cancer agents) - Coggle Diagram
Anti-neoplastic agents (Anti-cancer agents)
1) Alkylating Agents (Nitrogen Mustard)
Meclorethamine
Cyclophosphamide
Melphalan
Chlorambucil
Busulfan
Thiotepa
Metabolism leads to
nephron toxicity
to inhibit this toxicity
MESNA treatment
is given.
Acts on
G1 & S Phase
of Cell Cycle
2) Antimetabolites
A) Purine Antagonist
Mercaptopurine (6-MP)
Thioguanine (6-TG)
Azothioprine
B) Pyridine Antagonist
Fluorouracil
Floxuridine
Thymidylate Synthase
Indirect Thymidylate Synthase
Methotrexate
Leads to crystal formation (Kidney Stone)
Leucovorin
(Given simultaneously to overcome crystal formation)
Blocks the biosynthesis of Nucleic acid
Acts on
S Phase
of Cell Cycle
3) Antibiotics
Doxorubicin
Anthracycline and Anthracenediones
Leads to
cardiac toxicity
and to overcome toxicity
Dexrazoxane
is coadministered.
Daunorubicin
Dactinomycin
Bleomycin
DNA Topoisomerase II inhibitor
Blocks DNA transcription
Acts on
G2 phase
of cell cycle
Intercalation is done
Leads to point mutation
4) Plants Products
Etoposide
Vinblastine sulphate
Vincristine sulphate
Acts on
M Phase
of Cell Cycle
5) Miscellaneous
Cisplatin
Mitotane
Acts on
G1 & S Phase
of Cell Cycle
