Please enable JavaScript.
Coggle requires JavaScript to display documents.
ANS Affecting drugs - Coggle Diagram
ANS Affecting drugs
Parasympathetic
Receptors
Muscurnic
M1
M2
Location: Heart
agonist action
Bradycardia
antagonist action
tachycardia & :arrow_up: AV node conduction
M4
M3
Locations
GIT
agonist action
:arrow_up: perstalsis
antagonist action
:arrow_down: Peristalsis
UIT
agonist action
bladder contraction
antagonist action
Bladder relaxiation
Exocrine glands
agonist action
:arrow_up: Secretions
antagonist action
:arrow_down: Secretions
Eye
agonist action
miosis
antagonist action
Mydriasis
Airway
agonist action
bronchoconstricition
antagonist action
bronchodilation
M5
Location: CNS
agonist acction
procognative
antagonist acction
Anticognative
Nicotonic
Pharmaceutical actions
Parasympathomimetics
"Cholinomimetics"
Direct Muscarinic
Agonists
Examples
Bethanechol
Direct
CHOL
inergic agonists
Urinary retention
Carbachol
Decreases intraocular pressure in
Glaucoma (miosis)
Methacholine
Bronchial ("Methacholine") challenge
test
Pilocarpine
Tx for
Sjogren's Syndrome (salivation)
Dryeyes (lacrimation)
Sweat (Dx Cystic Fibrosis)
Indirect
Muscarinic
Agonists
Acetylcholinesterase
Inhibitors
Example
Neostigmine
Pyridostigmine
Acetylcholine-
STI
-nihibtors
Myasthenia Gravis
Physostigmine
Tx
Atropine overdose
Belladonna alkaloid poisoning
("deadly nightshade")
Rivastigmine
Donepezil
Alzheimer's Disease
Galantamine
Edrophonium
Diagnoses Myasthenia Gravis
Anti-Parasympathomimetics
Anticholinergics - block acytalcholein
Examples
Atropine
Tx of cholinergic poisoning
Unstable bradycardia
Scopolamine
Motion sickness
Benztropine
Extrapyramidal side effects
Trihexphenidyl
Extrapyramidal side effects
Oxybutynin
Overractive bladder
Dicyclomine
IBS
Glycopyrrolate
Siarrlorrhea, surgical HR control
Uses
Function like turning the sympathetic system
Ipratropium
COPD/Asthma
Sympathatic
