Please enable JavaScript.

Coggle requires JavaScript to display documents.

Gliomas - Coggle Diagram

- - - - Diffuse astrocytoma (IDH mutant)
        
        Grade 3
        
        Anaplasia: Present
        Mitosis: Present
        MVP/Necrosis: Absent
        No CDKN2A/B deletion
        
        Grade 4
        
        Anaplasia: Present
        Mitosis: Present or
        MVP/Necrosis or
        CDKN2A/B deletion Present or
        Combination of these
        
        Grade 2
        
        Well differentiated, No anaplasia
        Mitosis level: Low or null
        MVP/Necrosis: Absent
        No CDKN2A/2B deletion
      - Markers that predict progression in IDH mutant astrocytoma
        
        CDKN2A/2B homozygous deletion, CDK4 amplification
        PDGFRA amplification
        MYCN amplification
        Global DNA methylation levels
    - - Oligodendroglioma
  - - - (Diffuse) Astrocytoma IDH wild-type with molecular features of Glioblastoma, Grade 4
    - - (Diffuse) Astrocytoma IDH wild-type, Grade 2 or 3