Please enable JavaScript.
Coggle requires JavaScript to display documents.
Bioavailability, IMG_98EB62D7A61B-1 - Coggle Diagram
Bioavailability
Factors Affect
Biological
Surface Area
- small intestine > stomach
Permeability
- intestine membrane > stomach
Blood flow
- small intestine > stomach
pH
- affects dissolution - affect absorption
GI transit
- controlling step: gastric emptying
Physicochemical
- Partition Coefficient
- Ionization
- Polymorphism
- Particle Size
- Complexation
Transporters
- Energy dependant Efflux Transporter
- Transporter protein ( P-glycoprotein )
-
Metabolism
- First pass effect
- Genetic (diff CYP)
- Environmental (food)
- Drug-drug interaction
- Age (old: organ impaired)
- Disease (hepatitis)
-
Absolute vs Relative
-
Relative
= amount of drug that reach systemic circulation relative to different formulation (not IV eg: oral solution)
pakai bila takdak @ takle sediakan IV
-
-
Importance:
- calculate steady state plasma drug conc.
- calculate individualized drug dosage regimen
- asses bioequivalence between drug preparations
3 Parameters to measure
→ AUC, Cmax, Tmax
-
