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research ideation 2024, molecules/genes of interest, research ideation…
research ideation 2024
PMN
tumor-induced osteolysis
prevention with osteoblast:osteoclast ratio
cell signaling from adipocytes
TUMOR-INDUCED OSTEOCLASTOGENESIS
overview of the PMN
https://www.cell.com/cancer-cell/pdf/S1535-6108(16)30446-9.pdf
immune determinants of the PMN:
https://www.cell.com/cancer-cell/pdf/S1535-6108(23)00046-6.pdf
https://www.nature.com/articles/s41571-021-00499-9?fromPaywallRec=false
https://www.nature.com/articles/s41413-020-00105-1?fromPaywallRec=false
tumors originating in bone
osteosarcomas
U2OS cell line
osteosarcomal metastasis prevention by preventing osteolysis
osteoprotegerin
RANK/RANKL signaling
mTOR in osteosarcoma
mTOR signaling pathway
immunology
adipose-immune interactions
immune resistance
immune priming repression preceding metastasis
Th17 reduction
involves RANK signaling modulation
Immune determinants of the PMN:
https://www.cell.com/cancer-cell/pdf/S1535-6108(23)00046-6.pdf
macrphage differentiation and signaling
https://academic.oup.com/jbmr/article/38/3/359/7610238
tumor-evoked Bregs in metastasis
https://aacrjournals.org/cancerres/article/71/10/3505/567729/Tumor-Evoked-Regulatory-B-Cells-Promote-Breast
tumor assoc immune cells
https://link.springer.com/article/10.1007/S00109-013-1021-5
adipose biology
https://pubmed.ncbi.nlm.nih.gov/23500888/
progenitor development in bone
hormonal and paracrine control
by adipocytes
platelets in metastasis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801576/
molecules/genes of interest
OPG (osteoclast formation inhibition)
as a RANK/RANKL interaction blocker
RANKL also expressed by T cells, may play role in dentritic cell maturaiton and also macrophage differentiation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888234/
FGFR signaling in breast cancer
Galectin-3, a lectin [osteoclasts and secreted]
https://www.researchgate.net/figure/Clinical-presentation-of-bone-metastases-a-A-full-body-bone-scan-in-a-breast-cancer_fig6_301252751
MMP-2 in angiogenesis
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unique: histone deacetylases in bone/cartilage development affect cancer phenotypes?? Elizabeth Bradley
https://www.mayo.edu/research/faculty/bradley-liz-w-ph-d/bio-00027675
Hdacs are required to maintain bone density during aging
most bone metastasis occurs in aging women, connect Hdacs to bone metastasis???????
*
https://aacrjournals.org/mct/article/9/12/3210/93623/The-Histone-Deacetylase-Inhibitor-Vorinostat
https://www.sciencedirect.com/science/article/pii/S1084952122002944?casa_token=F7QSCS6HM34AAAAA:thWDCGbTIqTzrqqqM9Khq2y9ILe8dxnBKnX6cvwaqqTdJbbZegZ4SFAed2dugjI30KZscMiY
https://aacrjournals.org/mcr/article/7/8/1328/90499/NF-B-Activation-Dependent-on-Acetylation
https://link.springer.com/article/10.1007/s11914-021-00670-2
https://journals.physiology.org/doi/full/10.1152/physrev.00004.2015
https://academic.oup.com/jbmr/article-abstract/20/12/2254/7592984
macrophage cytokines
https://academic.oup.com/jbmr/article/38/3/359/7610238
NALCN
research ideation 2024
canine heartworm (D. immitis)
detection needs to wait 6-7 months before antigen tests work and microfilaria tests are unreliable early on
can we develop a better and cheaper test???
DNA tests????
antigens that are non-reproduction related???
resolving sensitivity problems and blocking by endogenous antibodies
look at other efficiant imroved detection tests as models
Wolbachia infects it!!!!
routes for cancer phenomena
altered metabolism
Noxa and glucose diversion and glucose to glutamine shiift
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862383/#:~:text=To%20study%20the%20signal%20transduction,and%20migration%20or%20differentiation%20characteristics
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HOW TO STUDY SIGNALING