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Complement Systems - Coggle Diagram
Complement Systems
Classical pathway
Trigger: Antibody-Antigen Complex
C5b
C5a
C5 Convertase: C4b2a3b
C3b
C3a
C3 Convertase: C4b2a
C4
C2
C1s
C1r
C1q
C1 Complex:
Lectin Pathway
Trigger: PAMPs (Pathogen-Associated Molecular Patterns) recognized by MBL (Mannose-Binding Lectin)
MBL
MASP-1 (MBL-Associated Serine Protease 1)
MASP-2 (MBL-Associated Serine Protease 2)
C2
C4
C3 Convertase: C4b2a
C3a
C3b
C5 Convertase: C4b2a3b
C5a
C5b
Common Terminal Pathway
C5b
C6
C7
C8
C9
MAC (Membrane Attack Complex): C5b-9
Biological Activities
Opsonization (C3b)
Inflammation (C3a, C5a)
Cell Lysis (MAC, C5b-9)
Chemotaxis (C5a)
Alternative Pathway
Trigger: Spontaneous hydrolysis of C3 or presence of foreign surfaces
Factors
Factors:
Factor B
Factor D
Factor H
Factor I
C3
C3 Convertase: C3bBb (stabilized by Properdin)
C3a
C3b
C5 Convertase: C3bBbC3b
C5a
C5b