Require TDM: Digoxin, ATB: Gentamycin , Vancomycin. Antiepileptic drugs: Phenobarbital Phenytoin, Dilantin, Valproic Acid, Carbamazepine. Psychoactive drugs: lithium,TCA(Tricyclic antidepressants). immun: Cyclosporine, Tacrolimus (FK506), Sirolimus, Antineoplastics: Methotrexate
Cardiac glycosides: Digoxin for CHF & cardiac arrhymias. inhibits membrane Na+, K+-ATPase--inside decrase K and increase Na. Plasme peak 2-3hrs.
Cardiac anti-arrhythmia:Quinidine. 80% bound to plasma proteins. 2. Procainamide – Rapid & complete absorption, 20% bound to plasma protein. 3. Disopyramide – Quinidine substitute, rapid absorption, variable in protein binding
Aminoglycosides. Toxicity: nephrotoxicity & ototoxicity. Gentamicin (-), Vancomycin for gram pos cocci & bacilli infection
Immunsuppressive: Cyclosporine (Eg. Gengraf) for organ transplant to prevent graft rejection. Tacrolimus (FK-506) replace. Sirolimus (Rapamune) to Prevent KI graft rejection. With cyc and tacro used. Mycophenolic Acid: Lymphocyte proliferation inhibitor, supplemental.
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