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ANTI- HISTAMINIC DRUGS, S/E:- Antiadrogenic Effect, Very less cross BBB-…
ANTI- HISTAMINIC DRUGS
H2 Blocker
- Cimetidine
- Ranitidine
- Famotidine
- Nizatidine
- Used in Peptic Ulcer Disease
- H2 Receptor increase the release of HCl from parietal cell of stomach - blocked - HCl decreases
-
H4 Blocker
-
- No drugs as of now
- But potential use in future can be in - Atopic Dermatitis
H1 Blocker
3rd Generation
- Levocetirizine
- Desloratadine - Most Potent
- Fexofenadine - Least sedating
- Bilastine
- Azelastine (Its nasal spray is used in allergic rhinitis)
1st Generation
- 1) Promethazine (2) Diphenhydramine (3) Dimenhydrinate
used in
a. Motion Sickness
b. Local Anesthetic
c. Chemotherapy induced Nausea and Vomiting
- 4) Doxylamine + Vitamin B6 :- Morning sickness (DOC)
- 5) Chlorpheniramine
- 6) Hydroxyzine:-
a.Antipruritic
b.Anxiolytic
c.Antiemetic
- 7) Meclizine
- 8) Cyclizine
- 9) Doxepin
Also used in non allergic rhinitis
2nd Generation
- Cetirizine:-
- Derivative of Hydroxyzine
- Most sedating 2nd generation drug
- Terfenadine:- Banned (QT increases)
- Loratadine
- Rupatidine
- Cinnarizine (Used in vertigo)
- S/E:- Antiadrogenic Effect
-
-
- Very less cross BBB- Non- sedating/ Less sedating
- More Potent
- Do not block muscasinic receptor
- DOC for Urticaria
- also used in allergic rhinitis and conjunctivitis
-
- Cross BBB- Highly Sedating
- Less Potent
- Block Muscarinic receptor - Anticholinergic effect - Highest in (Dimenhydrinate)
- Derivatives of earlier generation drugs
- Uses:-
- DOC for post operative aspiration pneumonia
- Peptic Ulcer