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DRUGS FOR OSTEOPOROSIS, Use- DOC-
a. Osteoporosis (Oral Drugs)
b.…
DRUGS FOR OSTEOPOROSIS
- Decrease Bone Resorption
Common S/E:- Hypocalcemia
ii. Denosumab
- MOA;- Block RANK Ligand
- Route:- S/C
- Use:- Post menopausal Osteoporosis with high risk of fractures
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i) Bisphosphonates
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IV
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- Most Potent
- Longest acting
- Block Farnesyl Pyrophosphate Synthase - Induces Osteoclasts apoptosis
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- (+)Bone Formation ( Anabolic Drugs)
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- Both
- (-)Bone Resorption
- (+)Bone Formation
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- Use- DOC-
a. Osteoporosis (Oral Drugs)
b. Hypercalcemia of Malignancy (IV)
c. Paget's disease (IV)
- S/E:-
a. Oral drugs;- Esophagitis
b. Bone fracture- Femoral chalk stick fracture
- C/I:- Renal failure
- PTH relate peptide analogue
- Use of Both:- Bisphosphonates induced fracture
- S/E:- Osteosarcoma
- C/I:- Paget's disease