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Diagnostic Pw for AIHA, + Further clinical +/- serological assessment -…

- - - - Consider alternative causes of HA
      - Repeat DAT by column agglutination method for IgG, IgM, IgA and C3d
      - Perform D-L test for children with haemoglobinuria (for testing PCH)
    - - Clinical assessment: look of the causes e.g. HTR, HDFN, DIHA, post transplantation (ABO mismatch), post IvIg, or some unrelated cause
        
        AIHA (of no alternative cause)
        
        DAT: IgG only
        
        Warm AIHA
        
        DAT: C3 +/- IgG
        
        DAggT (direct agglutination test) at RT
        
        Negative
        
        < 18 y.o.; Haemoglobinuria; Cold associated Haemolysis; Atypical features
        
        2 more items...
        
        Positive
        
        Antibody titre
        
        2 more items...