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ANAESTHESIA, Infiltration Anaesthesia, Adrenaline added for long action,…

- - - - Xenon
        
        Ideal anaesthetic
        
        Fastest acting
        Minimum blood gas partition coefficient
      - Nitrous oxide
        
        Maximum Minimal Alveolar Concentration
        
        Least potency
    - - Methoxyflurane (Most potent)
        
        Chloroform
        
        Ether
        
        Halothane
        
        Sevoflurane
  - - - Propofol (Day care anaesthetic)
        
        Thiopentone (Redistribution phenomenon)
        
        Ketamine (Dissociative anaesthesia)
        
        Etomidate
    - - Opioids
        
        Fentanyl
        
        Remifentanyl
      - Neuroleptic agents
        
        Droperidol
      - Benzodiazepines
        
        Lorazepam
        
        Diazepam
        
        Midazolam
- - - - Inhibit Polysynaptic reflexes
  - - - Dantrolene
        
        Block Ryanodine receptors in ER
        
        Hepatotoxic
        
        Used for Malignant hyperthermia
    - - Competitive
        
        Depolarizing
        
        Succinylcholine
        
        Shortest acting (<5 min)
        
        Hyperthermia
        
        Fasciculations
        
        C/I in nerve and muscle injuries (as it cause hyperkalemia)
        
        Leads to post operative muscle pain.
      - Non- Competitive
        
        Non- Depolarizing
        
        Curare
        
        Do not cause post operative muscle pain
        (releases Histamine)
        
        Broncho constriction
        
        Hypotension
        
        New Drugs (No Histamine release)
        
        Curium
        
        Atracurium
        
        Mivacurium
        
        Undergo Hoffman Elimination
        
        Spontaneous, non enzymatic inactivation by molecular rearrangement
        
        Used in liver and renal disease
        
        Curonium
        
        Pancuronium
        
        Pipecuronium