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HEMATOPOIETIC AGENTS, (Granulocyte Macrophage Colony Stimulating factor),…
HEMATOPOIETIC AGENTS
Drugs acting on Erythropoiesis
Erythropoietin(EPO) Analogues
Darbepoetin
Longer Acting
DOC for Anemia of Chronic Renal Failure, dialysis, etc.
Epoetin Alfa
Erythropoietin Receptor Agonists
Peginesatide
Drugs acting on Granulopoiesis
G-CSF Analogues
Lenograstim
Filgrastim
Lipefilgrastim
Pegfilgrastim
GM-CSF Analogues
Sargramostim
Drugs acting on Thrombopoiesis
IL- 11 Analogue
Oprelvekin
Thrombopoietin Agonists
Romiplostim
Eltrombopag
(Granulocyte Macrophage Colony Stimulating factor)
Less Potent
More Toxic
Lead to Capillary Leak Syndrome
(Granulocyte Colony Stimulating Factor)
More Potent
Less Toxic
Used in Anaemia of Chronic Renal Failure
Derivatives
A peptide that mimics biological activity of EPO