Relationship between Alzheimer's and people's ability to reason
Impact of Alzheimer's disease
Worldwide
Over 55 million people
Americans
More than 6 million
Americans who provide unpaid care
for people living with Alzheimer’s
More than 11 million
Alzheimer's and dementia
Alzheimer's
Dementia
Individual’s changes
Thinking
Reasoning
Memory
Most common cause of dementia
Progressive brain disease
Gets worse over time
Main features
Abnormal brain structures
Plaques
Tangles
Damage and kill
Nerve cells
Pieces of a protein fragment
Beta-amyloid
Spaces between nerve cells
Twisted fibers
Tau
Inside cells
Alzheimer's in the brain
Dr. Alois Alzheimer
More than 100 years ago
Described specific changes in the brain
Beta-amyloid plaques
Tau tangles
Impacts
Behavior
Thinking
Memory
Brain main parts
Cerebrum
Cerebellum
Brain stem
Fills up most of the skull
Most involved in
Rememberimg
Thinking
Problem-solving
Aproximately
100 billion nerve cells
Neurons
Send messages
Make feelings
Make thoughts
Make memories
Kills nerve cells
Kills nerve cells
Nerve cells die
Loss tissue
Shrinkage
Loss of function and communication
Between cells
Memory loss
Problems with thinking and planning
Behavioral issues
Last stage
Further decline in functioning
Trouble swallowing.
Stages of Alzheimer's disease
May live four to eight years
After diagnosis
Asymptomatic
Without symptoms
Biological changes of the disease
In their brain
Don't show any cognitive symptoms
Mild cognitive impairment
Can be an early stage
Memory loss
Loss of cognitive ability
Independent
Independently perform most activities of daily living
Symptoms
Forgetting important information
Appointments
Conversations
Recent events
Difficulty with
Making sound decisions
Judging the time
Recalling a sequence of steps
Needed to complete a complex task
Early stage
Symptoms
Trouble remembering names
Right word or name for something
New people
Difficulty with familiar tasks
Forget things
Recent readings
Getting lost in familiar places
Increasing trouble
Planning
Organizing
Middle stage
Forget
Events
One’s own personal history
Feeling
Angry
Withdrawn
Frustrated
Specially in
Socially challenging situations
Mentally challenging situations
Temporal-spatial desorientation
Trouble controlling
Bowels
Bladder
Needing help to choose the right clothes
Changes in sleep patterns
Higher risk of wandering
Becoming lost
Personality and behavioral changes
Becoming delusionak
Late stage
Lose awareness
Surrondings
Recent experiences
Changes in physical abilities
Sit
Swallow
Walk
Problems in the communication
Higher risk of infections
Treatments
Slow disease progression
Aducanumab Aduhelm
Lecanemab Leqembi
Side effects
Headache
Fall
ARIA
Changes in mental state
Confusion
ARIA
Infusion-related reactions
Treats cognitive symptoms
Memantine + Donepezil Namzaric
Rivastigmine Exelon
Donepezil Aricept
Galantamine Razadyne
Memantine Namenda
Treat symptoms related to
Judgment
Language
Thinking
Memory
Thought processes
Learning