Relationship between Alzheimer's and people's ability to reason

Impact of Alzheimer's disease

Worldwide

Over 55 million people

Americans

More than 6 million

Americans who provide unpaid care
for people living with Alzheimer’s

More than 11 million

Alzheimer's and dementia

Alzheimer's

Dementia

Individual’s changes

Thinking

Reasoning

Memory

Most common cause of dementia

Progressive brain disease

Gets worse over time

Main features

Abnormal brain structures

Plaques

Tangles

Damage and kill

Nerve cells

Pieces of a protein fragment

Beta-amyloid

Spaces between nerve cells

Twisted fibers

Tau

Inside cells

Alzheimer's in the brain

Dr. Alois Alzheimer

More than 100 years ago

Described specific changes in the brain

Beta-amyloid plaques

Tau tangles

Impacts

Behavior

Thinking

Memory

Brain main parts

Cerebrum

Cerebellum

Brain stem

Fills up most of the skull

Most involved in

Rememberimg

Thinking

Problem-solving

Aproximately

100 billion nerve cells

Neurons

Send messages

Make feelings

Make thoughts

Make memories

Kills nerve cells

Kills nerve cells

Nerve cells die

Loss tissue

Shrinkage

Loss of function and communication

Between cells

Memory loss

Problems with thinking and planning

Behavioral issues

Last stage

Further decline in functioning

Trouble swallowing.

Stages of Alzheimer's disease

May live four to eight years

After diagnosis

Asymptomatic

Without symptoms

Biological changes of the disease

In their brain

Don't show any cognitive symptoms

Mild cognitive impairment

Can be an early stage

Memory loss

Loss of cognitive ability

Independent

Independently perform most activities of daily living

Symptoms

Forgetting important information

Appointments

Conversations

Recent events

Difficulty with

Making sound decisions

Judging the time

Recalling a sequence of steps

Needed to complete a complex task

Early stage

Symptoms

Trouble remembering names

Right word or name for something

New people

Difficulty with familiar tasks

Forget things

Recent readings

Getting lost in familiar places

Increasing trouble

Planning

Organizing

Middle stage

Forget

Events

One’s own personal history

Feeling

Angry

Withdrawn

Frustrated

Specially in

Socially challenging situations

Mentally challenging situations

Temporal-spatial desorientation

Trouble controlling

Bowels

Bladder

Needing help to choose the right clothes

Changes in sleep patterns

Higher risk of wandering

Becoming lost

Personality and behavioral changes

Becoming delusionak

Late stage

Lose awareness

Surrondings

Recent experiences

Changes in physical abilities

Sit

Swallow

Walk

Problems in the communication

Higher risk of infections

Treatments

Slow disease progression

Aducanumab Aduhelm

Lecanemab Leqembi

Side effects

Headache

Fall

ARIA

Changes in mental state

Confusion

ARIA

Infusion-related reactions

Treats cognitive symptoms

Memantine + Donepezil Namzaric

Rivastigmine Exelon

Donepezil Aricept

Galantamine Razadyne

Memantine Namenda

Treat symptoms related to

Judgment

Language

Thinking

Memory

Thought processes

Learning