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2005 (GIS) - Coggle Diagram

- - - - drug of choice for motion sickness
  - - - treating postoperative and chemotherapy-induced nausea
      - not effective for motion sickness
  - - - acts as a 5HT4 agonist
    - - Tegaserod (tea garden)
        
        5HT4 agonist
      - Prucalopride (princess with pride)
        
        5HT4 agonist
      - Cisapride (sister with pride)
        
        5HT4 agonist (hERG)
      - Lubiprostone (lake)
        
        prostaglandin E1 analogue - activates ClC-2 chloride channels
        
        opioid-induced constipation
    - - cannot cross BBB
      - indications: food poisoning, overeating, hangover, migraine, heartburn
      - more useful than metoclopramide
  - - - acute and delayed nausea and vomiting associated with chemotherapy (cisplatin)
      - ondansetron is useless in delayed emesis
      - blocks binding of substance P to NK1 receptorand prevents emetic signal
  - - - pregnancy and NASA space motion sickness
  - - - crosses BBB
- - - - APOMORPHINE (used to treat Parkinson's)
        
        stimulates D2 receptors
        
        should not be taken if respiration is depressed
    - - mustard, sodium chloride
    - - ipecacuanha (ipecac)
        
        irritates gastric mucosa + CTZ (chemoceptive trigger zone)