DYSLIPIDEMIC DRUGS
i. Statins
ii. Intenstinal Cholesterol absorption inhibitors
iii. Fibrates
iv. Niacin (Vitamin B3)
v. Bile Acid Binding Agents (BABA)
MOA:-
HMG CoA(Require HMG CoA Reductase )
Mevalonate
Cholesterol
Statins (-) HMG CoA reductase
up-regulation of LDL receptors on liver surface
Cholesterol taken from blood
- Atorvastatin
- Rosuvastatin
- Pravastatin
- Simvastatin
- Fluvastatin
- Cerivastatin
MoA-
Inhibiting a pump in intestine called as Niemen pick like - C-1 pump (NPC 1L1). helps in absorption of cholesterol
- Ezetimibe
- Clofibrate
- Fenofibrate
- Bezafibrate
- Gemfibrozil (C/I in pregnancy)
- Inhibit lipolysis in adipocytes
- It causes maximum increase in HDL Cholesterol
and causes maximum decrease in Lipoprotein-A
- Cholestyramine
- Colestipol
- Cholesevelam
- Bill acids act as carriers and carry cholesterol from GIT to blood
- DOC in children, pregnancy and lactation
- Stimulate PPAR Gamma Receptor - Increase LPL
- Decrease LDL & VLDL
MOA:-