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DYSLIPIDEMIC DRUGS, HMG CoA(Require HMG CoA Reductase ), Statins (-) HMG…
DYSLIPIDEMIC DRUGS
i. Statins
- Atorvastatin
- Rosuvastatin
- Pravastatin
- Simvastatin
- Fluvastatin
- Cerivastatin
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Inhibiting a pump in intestine called as Niemen pick like - C-1 pump (NPC 1L1). helps in absorption of cholesterol
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- Clofibrate
- Fenofibrate
- Bezafibrate
- Gemfibrozil (C/I in pregnancy)
- Inhibit lipolysis in adipocytes
- It causes maximum increase in HDL Cholesterol
and causes maximum decrease in Lipoprotein-A
- Bill acids act as carriers and carry cholesterol from GIT to blood
- DOC in children, pregnancy and lactation
- Stimulate PPAR Gamma Receptor - Increase LPL
- Decrease LDL & VLDL
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