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Viral Infections - Coggle Diagram

- - - - HSV, Varicella Zoster, EBV, CMV, HHV-7, B virus, HHV - 8
      - Oral/Facial "cold sores" most common manifestation of HSV
      - Genital Herpes - Caused by HSV1, HSV2, HSV2 is more clinically unapparent
      - Herpetic Whitlow - Primary, recurrent, fingers or hands
      - Herpetic Keratoconjunctivitis - Initial corneal ulcer, leading cause of infectious blindness
      - Eczema Herpeticum - Widespread cutaneous HSV infection, loss of epidermal barrier, more common in patients with atopic dermatitis
      - Immunocompromised and HIV - More frequent, prolonged, severe infectons, deeper ulcers
      - Recurrent HSV and Erythema Multiforme: May develop 7-10 days after recurrent HSV infection, targetoid, vesicular lesions, usually acral location
      - Varicella - Hihgly contagious, eruption starts on face and scalp, spreads to trunk and extremities, can result in secondary bacterial infection
      - Varicella - Zoster: Primary infection from respiratory entry, hematogenous spread, chickenpox rash
      - Risk Factors
        
        Immunosuppresion, H.I.V infection, Transplants, Radiotherapy, Drugs -> Chemotherapy, high odse corticosteroids, Cancer -> Lymphoma, CLL, MM
      - Post-Herpetic Neuralgia
        
        Typically along dermatomes, burning pain, lancinating pain, and can be worsened by touch or contact
      - EBV
        
        Infectious Mononucleosis, Oral Hairy Leukoplakia
      - CMV
        
        Dermatologic manifestations rare and non-specific, perineal ulcers in paitents
      - Pityriasis Rosea
        
        Infectiious case -> Immune post infection, prodrome, herald primary
      - HHV-8
        
        Karposi's Sarcoma, and opportunistic neoplasm, atypical proliferation of vascular tissue, HSV
        
        Subsets of Kaposi's Sarcoma
        
        Classic, Immuno-suppression associated, endemic, AIDS related
    - - Variola (Small pox), ORF (contagious ecthyma), Milkers Nodule, Molluscum Contagiosum Virus
        
        Molluscum Contagiosum: Most common pox virus, papular exanthem, dome shaped, pink umbilicated papules
        
        Milker's Nodule: Acquired from cows, self limited
    - - Papillomavirus (warts)
        
        Transmission: Skin to skin contact from minor trauam with breaks in stratum corneum, sexual contact, typically in immunocompromised individuals
        
        Verruca Vulgaris: Firm papules with vegetations, can be linear, annular, butcher's warts or filiform warts
        
        Can be plantar warts that appear on hyperkeratotic surface, flat warts taht are sharply defined papules on flat surface
        
        Condylomata Acuminata: Papules or nodules on perineum, genitaelia, folds, anus
        
        Laryngeal Papiullomas: Associated with HPV-6, HPV-11, arise mostly on vocal cords
        
        HPV in immunocompromised: HIV patients suffer from increased HPV rates, present more larger, more numerous with increased duraation and length of diseas
        
        Immunosuppression and HPV-Rleated malignnacy: More common in immunocompromosied and present with more clinically severe neoplasias
  - - - Infects human CD4 T cells, Agent of AIDS, HIV infected paitents have cutaneous manifestations
      - Primary HIV Infection: HIV exposure, acute illness, fever 22
  - - - Hand foot, mouth disease, painful vesciular lesions, very contagious