Please enable JavaScript.
Coggle requires JavaScript to display documents.
Autoimmune disease - Coggle Diagram
Autoimmune disease
peripheral tolerance
T cell self-tolerance mechanisms
Suppression
Deletion
Anergy
overcome peripheral tolerance / self-tolerance
T cell
overcome Angery
impair Suppression
B cell
overcome Ignorance
B cell self-tolerance mechanism
Ignorance
B cells that encounter self antigens in peripheral tissues become anergic or die by apoptosis.
In some situations, recognition of self antigens may trigger inhibitory receptors that prevent B cell activation
central tolerance
T lymphocyte
occur in thymus
B lymphocytes
occur in bone marrow ?