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Histology/Histopathology of the Skin - Coggle Diagram

- - - - Components
        
        Collagen, Elastin, Fibroblasts
- - - - Multifactorial genetic and environmental upstream causes
      - Etiopathogenesis: Inflammation, dilated vessels, edema, cytokines, damaage, itch-scratch cycle
  - - - Mutlifactorial genetic and environmental upstream causes
      - Etiopathogenesis: T cell disroder -> Irritates normal maturation of epidermis -> Short transit time of keratinocytes from basal to stratum corneum
      - Itching, Rubbing -> thickened scales
    - - Thinned epidermis over dermal papillae with engorged superficial vessels
      - Remove the overlying scale -> Results in small pinpoints of bleeding at tips of thinned dermal papillae
      - Auspitz sign: Due to suprapapillary plate thinning, superficial vascular ectasia, inflammation that starts at tips of dermal papillae
- - - - Large nuclei, peripheral palisading, mucin, retraction artefact, mitoses, apoptosis/necrosis
  - - - Large nuclei, abundant glassy cytoplasm, desmoplastic stroma, mitoses, apoptosis/necrosis
  - - - Confluent, mitoses, cytologic atypia, destruction of epidermis and adnexal structures, pagetoid spread of melanocytes
- - - - Punch, shave excision, excisional