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Describe the ideal properties of an antiparasitic veterinary medicinal…
Describe the ideal properties of an antiparasitic veterinary medicinal product (VMP). Consider the pharmacokinetic and pharmacodynamic actions of relevant groups of antiparasitic VMPs available to analyse how these properties are met. (100%)
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intro - antiparasitics used to treat and manage endo and ecto parasites, there are multiple modes of action in order to control parasites this essay will discuss the phramacokinetic and dynamic actions of these medicine groups and relate this to the ideal properties of antiparasitic agents.
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ectoparasiticides
target external parasites, can be injectable or topical, therfore have an effect on the parasite on the surface, pharmacokineticks - transcutaneous absorption, systemic circulation / distribution - exposure to parasite
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endoparasites - usally given as (per os) tablets or liquids - need to act in ths GI tract as that is where worms are mainly present
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endectocides - target both ecto and endo parasites - route of administration and formulation will affect pharmacokinetics
macrocyclic lactones (avermectins) - activate glutamate gated chloride channels - chloride influx - hyperpolarises membrane inhibiting action potentials = paralysis
conclusion - there are many properties of ideal antiparasitic products, these have been discussed along with the associated pharmokinetics and dynamics. this essay has analysed how these properties are met. this analysis may contribute to the decision of what products to use.
essay tips from fay - overveiw of different drug MOAs in intro. discuss ideal properties initially, allows comparison of drugs to these properties. either split into MOAS or endo, ecto endecto - including relevant MOAs