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General pharmacology - Coggle Diagram

- - - - Easy
      - Safe
      - Self use
      - No need for sterilization
    - - Delayed onset
      - Nit suitable for unconscious patients
      - Some drugs are destroyed by digestive enzymes
      - Some drugs inactivated by first -pass metabolism
      - Not for irritant drugs to the GIT or in GIT disturbances
  - - - Rapid
      - Drug pass directly to the systemic circulation
      - Useful for drugs destroyed by GIT
      - Excess drug can be easily removed
    - - Not suitable for drugs that cause V.C of subligual mucosa
  - - - Advantages
        
        Drugs that irritate the stomach
        
        Suitable for children and unconscious patients
        
        The effect of digestive enzymes can be avoided
        
        Drugs pass directly to the systemic circulation
    - - Rectal absorption is irregular
      - May cause irritation of the rectal mucosa
  - - - Rapid complete : drug bioavailability
      - Used in emergency
      - Large amount of fluid can be given irritant drugs can be used
    - - Disadvantage
        
        Leakage outside the vein may produce
        
        Undesirable reaction are more frequent
        
        Velocity reaction
      - Severe irritation
      - Transmission of diseases
- - - - Transfer of drug from its site of administration to the blood stream
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