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angiotensin receptors in the regulation of blood pressure and renal…
angiotensin receptors in the regulation of blood pressure and renal function
RAAS
classic, tissue or intracellular
feedback loop on classic system
volume depletion or decreased MAP
secreted by JGA cells of renal afferent arterioles
pro renin
renin
.
angiotensin I
1 more item...
endocrine, paracrine and intracrine system
ANG2 at AT1
Na reabsorption
stimulate aldosterone release by the adrenal zona glomerulosa cells
water reabsorption
vasoconstriction
binds to arterial and smooth musle
pre and post glomerular resistance vessels
constricts globular mesangial cells
other receptors
of ang I
ACE 2 creates ANG 1-9 one peptide off
ANG II
ACE II
ANG 1-7
Mas receptor, vasodilation, antithrombotic
AT-2 receptor
vasodilation, NO release, decrease inflammation, inhibition of cell growth, induces natiuresis
AMPA
ANG III
AT-1 (same)
AMPM
ANG IV
AT-4
vasodilation, glucose metabolism, proinflammatory, procogulant, cell growth
AT1 and AT2 receptors
AT2R
expressed in adult kidney in renal proximal tubule
BK up , NO up, so cGMP up
vasodilation, natrieuris
BP down
AT1R
cAMP down, VSM contraction
prox tubulal sodium reabsorption up
aldosterone up, distal tubule sodium reabsorption up
vasocontrction, anti-natriuresis
BP up
case studies
ang II infusion model of experimental hypertension using the highly selective AT2 receptor agonist C-21
agonising the receptor that causes vasodilation causes vasodlation
Kemp et al.
urine Na+ excretion and MAP measurements in volume expanded female sprague dawley rats
AR2R activaiton with receptor agonist C-21 si inc urinary Na ecretion in a dose dependant manner
C-21 administration activates AR2Rs inducing natrieresis in a bdradykinin down, NO down and cgmp DOWN DEP MANNER
AT2R activation induces recpetor recruitment to the apical plasma membranes of the PTC
how?
AT2Rs induce natriuresis bu internalisaing/inhibiting NHE3 from the apical to subapical region in PTC
ANG II induced increase in SBP and anti-natrieusis blcoked by intrarenal administation of C-21
sprague dawley
curently no pharma availbile
renal AT2R activation prevents Na rentetion and lowers bp in ANG II dep hypertension
thus AT2R activation may rep a novel approavh in treatment of fluid retainign states and hypertension
angiotensinogen (liver)