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Neurotransmitter transportes - Coggle Diagram
Neurotransmitter transportes
Superfamiliy
a) Plasma membrane neurotransmitter transporter
Family
Na/Cl dependant
SLC6
Structure: 12 transmembrane domain; Large loop between (2-4); C & N terminal intracellular
Subfamily
Noradrenaline Transporter
Dopamine Transporter
GABA Transporter
Glycine Transporter
Serotonin Transporter
Na/K dependant
SLC1a
Structure 6-10 transmembrane domain; N and C terminal intracellular
Subfamiliy
Excitatory amino acid (EAA) transporter: glutamate and aspartate
b) Vesicular neurotransmitter transporters
Neurotransmitter storage; leakage or interneuronal metabolism or toxicity
Driven by proton gradient; Counter transporter , by hydrogen ion
Low affiinity compared to plasma membrane
Family
VAchT
Vesicular acetylcholine transporter
VIAAT
vesicular glycine/GABA trasporter
10 transmembrane domain; Long N terminal and short C
Vglut1/Vglut2/Vglut3
Putative vesicular glutamate transporter
VMAT1; VMAT2
Vesicular amine transporters (5-HT, DA, Histamine, NAd)
12 transmembrane domains, Loop between 1-2); C and T terminal intracellular
Enzymatic Degradation
Acetylcholintransferase
Acetylcholine = Acetyl + Choline
Choline taken up by Choline transporter
Glutamate
EAAT1
Primary glial
Astocytes
EAAT-2
Glial & neuronal
EAAT-3; EAAT-4
primary neuronal
EAAT-5
retinal
GABA
GAT-2
GAT-3