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Immune Response in Various Oral Disorders, Immune System Disorders with…
Immune Response in Various Oral Disorders, Immune System Disorders with Oral Manifestation
Immunology in dental caries
Immunity in dental caries: prevention by physical barriers, natural immune (saliva, enamel, mucosal epithelia), innate immunity (lysozyme, peptidoglycan), adaptive immunity (sIgA)
Dental caries: infectious microbiologic disease of the teeth that results in sectorial dissolution and destruction of the calcified tissue
Immunology in oral mucosa infection
Immune system in the oral mucosa is diverse, with various types of immune cells playing important roles in protecting against infection and maintaining homeostasis
It helps maintain balance with microbial diversity and tolerance mechanisms also fight off disruptions and diseases such as infections and autoimmune diseases
Immunology of the oral mucosa is characterized by a complex interplay between the immune system and the oral microbiota
Immunodeficiency and oral manifestation
Immunocompromised patients' oral manifestations include mucositis, infections (viral, fungal, and bacterial), and a higher risk of oral cancer
Immunodeficiency: body's immune system is weakened, can happen in primary (genetic) and secondary (other factors)
Immunology in oral neoplasm
F-κB pathway is crucial for cancer development and progression, stimulating the expression of inflammatory responses and lymphocyte development. Tumor-associated macrophages produce VEGF and matrix metalloproteinases, promoting tumor growth and spread
T lymphocytes play a key role in immune protection by killing tumor cells through CD8 + CTLs
Oral neoplasm: oral cancer, malignant neoplasia from lip or oral cavity
Immunology in autoimmune and allergy and their oral manifestations
Allergies: immune system response to a normally harmless substance (allergen)
Autoimmune: immune system wrongly identifies "self" as "non-self"
Oral manifestations of autoimmune and allergic disease: Sjogrens syndrome, SLE, pemphigus vulgaris, behcet's disease, aphthous ulcers
Immunology in periodontal diseases
Homeostasis --> Dysbiosis --> Periodontal disease
Innate immunity is the first response in periodontal diseases with neutrophils as the first cells to respond
Specificity: adaptive immunity focuses on specific infections, memory recalls previous infections to allow for a faster response in the futuere
Humoral immunity refers to antibodies produced by B cells, cell-mediated or cellular immunity refers to T-cells directly targeting the infected cells
Nasywa Azzahra Sudaryono - 2306173731
