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Adrenergic blocker - Coggle Diagram

- - - - negative inotropic and chronotropic effects
      - increasing peripheral vascular resistance
      - -Bronchoconstriction:
      - Disturbances in glucose metabolism:
      - uses
        
        hypertensive
        
        angina pectoralis
        
        MI
        
        migrain
        
        hyperthyrodism
      - Drug interactions
        
        stimulate its metabolism,
        
        barbiturates, phenytoin, and rifampin
        
        inhibit metabolism
        
        cimetidine, fluoxetine, paroxetine, and ritonavir
    - - uses
        
        timolol
        
        reduce aqueous humor in eye
        
        chronic open-angle glaucoma
  - - - First-line therapy for chronic stable angina
      - Hypertensive patients with impaired pulmonary function
    - - chronic heart failure
    - - weakly stimulate both β1 and β2 receptors and are said to have ISA
        
        hypertensive patients with moderate bradycardia
        
        not used for stable angina
    - - only available intravenously
    - - releases nitric oxide from endothelial cells and causes vasodilation.
- - - - selective Alpha-1 blocker(α1B)
      - treatmen hypertensive
    - - selective for α1A receptors in the prostate and bladder
      - treatment of benign prostatic hyperplasia
    - - Tachycardia
      - CHF if used alone in hypertension.
      - Dizziness, drowsiness, headache, nasal congestion
      - Floppy iris syndrome
  - - - 24 hr effect
        
        Pheochromocytoma ,Reynaud'sdisease, Frostbite.
    - - short effect
    - - Decrease peripheral resistance
      - Increase in the release of norepinephrine
      - Epinephrine reversal
- - - - hypertensive emergencies