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Peptic Ulcer, Atiacids, Histamine2 receptor antagonists, Proton pump…
Peptic Ulcer
Clincal manifestations
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Nausea, vomiting (haematemesis)
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Features
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Gastric ulcer
Chronic ulcers tens to occur in the lesser curvature of the stomach, near the pylorus
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Occur mainly in gastroduodenal mucosa
[tissue cannot withstand the digestive action of gastric acid and pepsin]
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Medication
Antacids
Magnesium hydroxide (Triact, Mucaine)
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Proton pump inhibitors
[taken before meal, more potent than H2 blockers]
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Surgery
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Types
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Antrectomy and Vagotomy
·Small segment of duodenum, the pylorus and the antrum is resected · the stump of the duodenum is closed by suture and the side of the jejunum is anastomosed to the cut end of the stomach
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Proton pump inhibitors
Indication
Severe erosive GERD, not responsive to H2 receptor anatagonist therapy
Anti-Helicobacter pylori therapy (Standard triple therapy, PPI + Clarithromycin + amoxicillin/ metronidazole)
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