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ANTI CANCER THERAPY, Anthracyclines, doxorubicin, bleomycin, Multidrug…
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Multidrug resistance
(P-glycoprotein)
adenosine triphosphate–dependent pumping of drugs out of the cell in the presence of P-glycoprotein.
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verapamil
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inhibit the pump and, thus, interfere with the efflux of the anticancer agent.
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Severe vomiting, bone marrow suppression, and alopecia occur to varying extents with most antineoplastic agents
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Paclitaxel
docetaxel , which is the more potent of the two drugs
prostate, breast, GI, and non–small cell lung cancers
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Tumor lysis syndrome
metabolic disturbances, including hyperuricemia and hyperkalemia
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MICROTUBULE INHIBITORS
affecting the equilibrium polymerized and depolymerized forms of the microtubules
;G2/M phase of the cell cycle
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