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CLASSIFICATION OF QUINOLONES - Coggle Diagram
CLASSIFICATION OF QUINOLONES
Non fluorinated
1 generation
NALIDIXIC ACID
bacteria especially proteus, klebsiella,e coli shigella but not pseudomonas
less active against gram +
Bactericidal against gram - bacteria
FLUORINATED
2 GENERATION
Expanded gram - activity
Limited/no gram = activity
Ciprofloxacin ,Ofloxacin,Norfloxacin ,Lomefloxacin
3 GENERTAION(respiratory flouro...)
Retained Expanded gram - activity
Impoved gram +activity
Levofloxacin ,sparfloxacin ,gatifloxacin
4 generation
Clinafloxacin ,Moxifloxacin
Broadest spectrum
maximally improved gram + act,retained gram - act,anaerobic antimicrobial activity