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MIGRAINE + Obesity, MIGRAINE, Obesity, appetite suppressants., selectivity…

- - - - vasoconstriction
      - inhibition of the release of pro-inflammatory neuropeptides
    - - parenteral drug
        
        Headache commonly recurs within 24 to 48 hours after a single dose
    - - CONTA I.
        
        CVS problems
  - - - intravenously
        
        nausea is a common adverse effect.
- - - - No dosage adjustments are required in patients with renal or hepatic dysfunction
  - - - ( --- )fat-soluble vitamins and β-carotene
- - - - stimulant phentermine was added to counteract the sedation and promote additional weight loss
        
        should not be stopped abruptly as seizures may be precipitated
      - cleft palate
      - contraindicated in pregnancy.
      - Paresthesias
      - reduce the efficacy of oral contraceptives
- - - - ↑ levels of neurotransmitters in the brain
        
        ↑ in norepinephrine signals a “fight-or-flight” response by the body, which, in turn, ↓ appetite."
- - - - "↑ dosage usually does not result in further weight loss, and discontinuation of the drug is usually recommended once the plateau is reached.