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Adrenergic agonist - Coggle Diagram
Adrenergic agonist
Mixed action
induce release of nor epinephrine. and activate adrenergic receptors
Ephedrine & pseudoephedrine
used in hypotension
slow onset bronchodilator
Pseudoephedrine used in nasal and sinus congestion but with precautions
Indirect acting agonists
Increase release of epi & nor epi
amphetamine and tyramine
Inhibit re-uptake of epi & nor epi
cocaine
Inhibit degradation of epi & nor epi
MAO & COMT
inhibitors
Direct acting agonists
Selective
Dobutamin
β1 agonist
acute HF
after cardiac surgery
Albuterol, metaproterenol & terbutaline
β2 agonist
Terbutaline injection relax uterus so Used in premature labor
bronchodilator(inhaler)
Short acting (3 hr)
Salmeterol, indacaterol & formoterol
long acting 12hr
Oxymetazoline
ophthalmic & nasal decongestant
α 1 & α2 agonist
Phenylephrine
Selective α1 agonist
nasal or oral decongestant
Hypotension in patient with rapid H rat
Ophthalmic solution for mydriasis
Clonidin
Selective α2 agonist
Used to in hypertension by inhibiting sympathetic
in ADHD
non-slective
Adrenalin
CVS
+ve inotropic & +ve chronotropic effect
Constriction of arterioles
renin release,
Respiratory
Bronchodilation
Inhibit allergy mediators release
Intraocular surgery (Mydriasis)
Noradrenalin
same adrenaline but stronger
not use for asma and anphylactic
brady cardia occure (vagal stimulation)
Isoprenaline
Non selective β-1 , β-2
Dopamin
acts on D1-2 dopamine Receptors
D1
dilatation of renal, mesenteric bv
D2
just like α2 receptor
Cardiogenic & septic shock
Hypotension
Severe heart failure.
Fenoldopam
agonist D1
Rapid vasodilator so used in sever hypertension