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GI pathology Yr 3 - Coggle Diagram
GI pathology Yr 3
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Liver
Hepatitis
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Hepatitis A: food borne, self limiting, rarely causes serious hepatic injury
Hepatitis B: blood borne, rarely causes chronicity in older population but high chronicity in vertical transmission (Hep D can only coexist with Hep B)
Hepatitis C: blood borne, highest rate of chronicity
Hepatitis E: food bourne, usually self limiting, most common cause of liver failure in developing countries
Fatty liver disease
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Alcoholic fatty liver disease: 35 drinks/week in women, 42 in men
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Colon
Ulcerative colitis
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- affects large intestine only
- starts from rectum & continues retrograde spread
- continuous inflammation
- shallow broad ulceration
- limited to the mucosa and submucosa
- form crypt abscesses
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Crohn's disease
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- most commonly affects terminal ileum & caecum
- affects all layers of the GIT: mucosa, SM, Muscularis
- can form fissures & deep knife like ulcers
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Small intestine
Duodenal ulcers
90% associated with H pylori infection, other causes inclue Zollinger-Ellison syndrome
- jejunum ulcers almost diagnostic of zollinger ellison
Coeliac disease
Autoimmune disease of the small intestine - type 4 hypersensetivity. Th2 cell mediated response to gliadin in the breakdown of gluten
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