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Biology AS 3.1 - 3.4 - Coggle Diagram
Biology AS 3.1 - 3.4
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3.4: DNA, Genes and Chromosomes
3.4.1.1: Prokaryotic DNA
- The DNA in prokaryotic cells is significantly different from the DNA found in eukaryotic cells
- Prokaryote” means “before the nucleus”
The DNA is double-stranded
- Prokaryotes possess a single, circular chromosomal DNA molecule
- It is sometimes referred to as a nucleoid
- They also usually have one or more plasmids
- Plasmids are very small circular DNA molecules
- They usually only contain a few genes
- Plasmids are more accessible for proteins required for gene expression and therefore contain genes that are required often, quickly and/or in emergencies
- The genes for antibiotic resistance are often found in plasmids
- The DNA within prokaryotic cells is not associated with any proteins
- Eukaryotic DNA associates with histone proteins
3.4.1.2: Eukaryotic DNA
- Chromosomes are made of one very long, condensed DNA molecule associated with proteins (in eukaryotic cells)
- The main proteins present are the large positively charged globular proteins called histones, their role is to organise and condense the DNA tightly so that it fits into the nucleus.
- The other proteins are enzymes used in copying and repairing the DNA
- The tightly coiled combination of DNA and proteins is called chromatin – this is what chromatids, and therefore chromosomes, are made of
- During interphase (S phase) the DNA replicates to create two identical strands of DNA called chromatids, joined together by a narrow region called the centromere.
- The two chromatids that make up the double structure of a chromosome are known as ‘sister chromatids’
- It is important that the sister chromatids are identical (contain the same genes) because this is key to cell division, as one chromatid goes into one daughter cell and one goes into the other daughter cell during mitosis, ensuring the daughter cells are genetically identical.
- Each chromatid is made up of one very long, condensed DNA molecule, which is made up of a series of genes.
- The ends of the chromatids in chromosomes are ‘sealed’ with protective structures called telomeres
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