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Drugs for Constipation and Bowel Cleaning (Laxatives and Purgatives), C/I-…
Drugs for Constipation and Bowel Cleaning (Laxatives and Purgatives)
Novel (Newer) Drugs
Chloride Secreting Agents
Linadotide
Lubiprostone
NHE 3 Blocker
Tenapanor
Peripheral Opioid Antagonists
Methylnaltrexone
Naloxegol
Alvimopan
Naldemedine
Bulk Forming Agents
Stool Softening Agents
Surfactants
Docusate Sodium
Docusate Calcium
Mineral Oil
Stimulant Purgatives
Castor Oil
5HT4 Agonist
Prucalopride
Anthraquinones
Cascara Sagrada
Senna
PG Analogue
Lubiprostone
Diphenylmethanes
Na Picosulfate
Bisacodyl
Osmotic Laxatives
Non-Digestible sugars
Lactulose
Lactitol
Mannitol
Sorbitol
PEG (Polyethylene Glycol)
DOC for IBS with constipation
Saline laxatives
Mg(OH)2
Mg citrate
Na3Po4
MgSO4
C/I-
Renal Failure
Prebiotics
Dietary Fibres
Bran
Methyl Cellulose
Psyllium Husk
Stimulate normal microbial flora
Should be given with high water intake
(Rarely used)
Cause Aspirational Pneumonitis
MOA- Decrease Surface tension of stools
Stool Collapse and pass out easily
MOA- Promote low grade inflammation in intestine
Irritation of Nerve Endings
Contraction of Intestine
Effects is seen after 6-8 Hours
Hence, taken at night
MOA- Sugar is Osmotically active
Draws water with them
Na 2+ Exchanger-3
Direct Cl channel 2 Activator
(Isabgol or Ispaghula)
(Metabolised into Ricenolenic acid)
Use-Bowel cleaning before procedures