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VDJ recombination, RAG endonuclease cuts a few bases on one strand for one…

- - - - DJ recombination
        
        V (DJ) recombination
        
        DNA in between each segment is spliced out
  - - - chromo 22
      - difference: all J segments are adjacent a constant region gene
    - - chromo 2
      - difference: all J segments are adjacent each other
- - - - action of Tdt
    - - affects V(D)J segments
      - narrow window in B cell development where this occurs
      - AID (activation induced cytosine deaminase)
        
        enzyme converts cytosine to uracil
        
        purposeful DNA damage to drive mutation
        
        end goal is to increase the affinity of the antibody for the antigen
        
        affinity maturation
- - - - process called microhomology alignment
      - section of comp may not be at the end of overhang, so non homo nucleos are exonucleod off
        
        DNA pol fills in gaps