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Haemostatic Drugs - Coggle Diagram

- - - - hypotension
- - - - Op : 0 platelets (used for thrombocytopenia)
      - 'elve' : eleven (analogue for IL-11)
      - kin : interleukin
      - used for patients undergoing cytotoxic chemotherapy for nonmyeloid cancers
    - - stimulates thrombopoetin receptors
      - approved for treatment of idiopathic thrombocytopenic purpura (ITP)
    - - 'El': elimizi ilaç içmek için kullanıyoruz
      - orally active agonist of thrombopoetin receptor
      - restricted use because of risk of hepatotoxicity and hemorrhage
  - - - iron sucrose (Venofer) - should be given intravenously
      - Ferumoxytol
        
        may interfere with MRI imaging (should be done before treatment)
    - - can stain teeth, cause nausea/vomiting
      - Ferrous sulfate (Tardyferon)
      - Ferrous fumarate (Feramat)
      - Ferrous gluconate
      - Gynoferrosanol / Gynoferon have additional B12 or folic acid - can be prescribed to pregnant/lactating women
    - - Acute iron intoxication
        
        parenteral administration of deferoxamine (chelates excess iron)
      - Chronic iron intoxication
        
        oral iron chelator deferasirox
  - - - agonist of erythropoietin receptors expressed by red cell progenitors
      - clinical application: anemia, especially associated with chronic renal failure
      - no oral preparations, only parenteral
    - - lus = less, cept = interception
        
        less interception with TGF-beta
      - TGF-beta is responsible for signaling cascades that inhibit maturation of RBCs
      - restores RBC's ability to differentiate
  - - - orally active
      - tyrosine kinase inihibitor
      - decreases antibody-mediated platelet destruction
  - - - 'fil': fill the stem cells
      - recovery of neutrophils
      - treatment of secondary and primary neutropenia
    - - 'peg': packs stem cells
      - long-acting form of filgrastim
      - covalently linked to a type of polyethylene glycol GM-CSF (sargramostim)
    - - antagonist