TRYPANOSOMA CRUZI
TRYPANOSOMA CRUZI CAUSE CHAGAS DISEASE. DISCOVERED BY CAELOS CHAGOS
ISOLATED FROM REDUVIID BUG (TRIATOMINE BUGS)HAD BLOOD MEAL FROM INFECTED MONKETS
HABITAT
IN BLOOD (TRYPOMASTIGOTE)
RETICULOENDOTHELIAL SYSTEM (AMASTIGOTE)
MORPHOLOGY
AMASTIGOTE- 1-5 4
ROUND OR OVAL SHAPED
SPINDLE SHAPE 20
INDISTINGUISHABLE FROM LEISHMANIA
TRYPMASTIGOTE SEEN AS C OR U FORM
LIFE CYCLE
HAS LESS MOTILE, MORE MOTILE
INVERTEBRATE HOST- INTAKE OF BLOOD MEAL BY BUG FROM INFECTED POERSON
THEN IT RUPTURE
CONVERT INTO TRYPOMATIGOTES IN PSEUDOCYST
ATE IN TRYPOMASTIGATE FROM
PSEUDOCYST FORMATION
AMASTIGOTE I
TRANSFORM TO AMASTIGATE ,MULTIPLY BINARY FISSION
MULTIPLY BINARY FISSION
VERTEBRATE HOST - METACYCLIC TRYPMASTIGOTE WHEN BUGS BITES MAN, ALSO LAY FAECAL MATTER INVADE BY RUBBING OF SKIN
EPIMASTIGOTE IN MIDGUT
INFECTIVE FORM -METACYCLIC TRYPMASTIGATE
METACYCLIC TRYPOMASTIGOTE IN HINDGUT
VERTEBRATE HOST-HUMAN , INVERTEBRATE HOST -REDUVIID BUGS OR KISSING BUGS OR TRIATOMINE BUGS
RELEASED OUT IN FAECAL MATTER IN HUMANS
IF THEY START RUBBING IT WILL CAUSE INFECTION
PATHOGENECITY
LYMPADNETITUIS,HEPATOSPLENONOMEGALY
ACUTE MYOCARDITIES(INFLAMMATION OF HEART MUSCLES
ROMANAS SIGN, CONJUCTIVITIES
DILATION OF OESOPHAGES, REGUGITATION ,DYSPHAGES
CAUSE CHAGOMA (NODULE)
CONGENTITAL TRANSMISSION STILL BIRTH, LOW BIRTH WEIGHT
LAB DIAGNOSIS
CULTURE- NNN MEDIUM, VAGERS LIVER INFUSION TRYPTORE MEDIUM
WET COUNT ,GIEMSA STAIN
CONFIRMATORY TEST , XENODIAGNOSIS
TREATMENT
NIFURTIMOX
BENZNIOLAZOLE