TRYPANOSOMA CRUZI CRUZI 1

TRYPANOSOMA CRUZI CAUSE CHAGAS DISEASE. DISCOVERED BY CAELOS CHAGOS

ISOLATED FROM REDUVIID BUG (TRIATOMINE BUGS)HAD BLOOD MEAL FROM INFECTED MONKETS

HABITAT

IN BLOOD (TRYPOMASTIGOTE)

RETICULOENDOTHELIAL SYSTEM (AMASTIGOTE)

MORPHOLOGY CRUZI MORPHOLOGY 3

AMASTIGOTE- 1-5 4

ROUND OR OVAL SHAPED

SPINDLE SHAPE 20

INDISTINGUISHABLE FROM LEISHMANIA

TRYPMASTIGOTE SEEN AS C OR U FORM

LIFE CYCLE

HAS LESS MOTILE, MORE MOTILE

INVERTEBRATE HOST- INTAKE OF BLOOD MEAL BY BUG FROM INFECTED POERSON

THEN IT RUPTURE

CONVERT INTO TRYPOMATIGOTES IN PSEUDOCYST

ATE IN TRYPOMASTIGATE FROM

PSEUDOCYST FORMATION

AMASTIGOTE I

TRANSFORM TO AMASTIGATE ,MULTIPLY BINARY FISSION

MULTIPLY BINARY FISSION

VERTEBRATE HOST - METACYCLIC TRYPMASTIGOTE WHEN BUGS BITES MAN, ALSO LAY FAECAL MATTER INVADE BY RUBBING OF SKIN

EPIMASTIGOTE IN MIDGUT

INFECTIVE FORM -METACYCLIC TRYPMASTIGATE

METACYCLIC TRYPOMASTIGOTE IN HINDGUT

VERTEBRATE HOST-HUMAN , INVERTEBRATE HOST -REDUVIID BUGS OR KISSING BUGS OR TRIATOMINE BUGS

RELEASED OUT IN FAECAL MATTER IN HUMANS

IF THEY START RUBBING IT WILL CAUSE INFECTION

PATHOGENECITY

LYMPADNETITUIS,HEPATOSPLENONOMEGALY

ACUTE MYOCARDITIES(INFLAMMATION OF HEART MUSCLES

ROMANAS SIGN, CONJUCTIVITIES

DILATION OF OESOPHAGES, REGUGITATION ,DYSPHAGES

CAUSE CHAGOMA (NODULE)

CONGENTITAL TRANSMISSION STILL BIRTH, LOW BIRTH WEIGHT

LAB DIAGNOSIS

CULTURE- NNN MEDIUM, VAGERS LIVER INFUSION TRYPTORE MEDIUM

WET COUNT ,GIEMSA STAIN

CONFIRMATORY TEST , XENODIAGNOSIS

TREATMENT

NIFURTIMOX

BENZNIOLAZOLE