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NMJ and Muscle Disorders - Coggle Diagram

- - - - Ocular
        
        Ptosis, Double vision
      - Bulbar
      - Limbs and Trunk
- - - - Examines electrical signals of motor units to differentiate myopathic and neurogenic process
  - - - Acute/Subacute onset, weaknes that isn painless (proximal, neck flexors, eye muscles spared)
    - - Heliotrope rash, Gottron, papules calcinosis
    - - Increased CK, Autoantibodies, EMG that shows abnormal spontaneous activity, biopsy demonstrating inflammatory infiltrate, and perifascicular atrophy
    - - Lung, Heart, G.I
    - - Corticosteroids, other immune suppressants
  - - - Cause
        
        Non-sense mutations
      - Clinical Features
        
        Delayed motor milestones, toe walking, enlargement of calf muscles
        
        Protrubent abdomen, waddling gait, proximal, leg weakness
        
        Gower's sign
      - Lab Features
        
        Very high CK, and biopsy demonstrating degeneration and fibre necrosis
  - - - Diseases where normal contractile process is distorted by involuntary persistent muscle acitvity and abnormal repetitive discharge
    - - DM1: Expanding trinucleotide repeat
      - dm2: Expoanding tetranucleotide repeat
      - Prewsentation
        
        Myotonia, Weakness distal, frontal balding, ptosis, long face, slack mouth
  - - - Most common ion clinical practice
      - Requires high dose
    - - from HMG-CoA inhibitors