Please enable JavaScript.

Coggle requires JavaScript to display documents.

Lymphoid Malignancies - Coggle Diagram

- - - - T-NHL
      - B-NHL
        
        Follicular
        
        Diffuse large B cell lymphoa (DLBCL)
        
        Burkitt's lymphoma
        
        Mantel cell lymphoma
        
        Primary CNS lymphoma
  - - - Stages I-IV
        
        I - One lymph node
        
        II - Two lymph nodes at one side of the diaphragm
        
        III - Both sides of the diaphragm
        
        IV - Extranodal
      - A or B
        
        A - No symptoms
        
        B - 3 symptoms
        
        Night sweats
        
        Weight loss of more than 10% of body weight
        
        Swinging night fevers
  - - - Tells you if the tumour is high o low grade
  - - - Native - Rituximab
      - Conjugated - BV
    - - Small molecules which attack specific intracellular pathways
    - - Allogenenic transplant
      - CART
  - - - Intercalate into DNA and produce free radicals
    - - Cross link DNA and stop mitosis
    - - Disrupts spindle body formation
    - - Toxic to all lymphocytes
    - - Myelotoxicity
      - Alopecia
      - Nausea
      - Infertility
- - - - ABVD x 2-6 courses +/- radiotherapy
  - - - Night sweats
      - Weight loss
      - Swinging night fevers
- - - - No advantage in treating asymptomatic dsease
    - - R-CVP
      - R-CHOP
      - R2
      - ...
- - - - Rituximab
      - Cyclophosphamide
      - Antracycline
      - Vincristine
      - Prednisolone
- - - - Commonest malignancy in Caucaisnas
      - Median age 70
      - M>F
    - - By chance - routine FBC
      - Recurrent infections
      - Enlarged lymph nodes
      - Marrow failure
        
        Anaemia
        
        Thrombocytopenia
      - Autoimmune disorders
    - - Produce 1 type of lymphocyte in place of all others
    - - No treatment
        
        Watch and wait
        
        Treat infx
        
        Watch for seconday malignancy
      - Treatment
        
        R-chemo
        
        Antibody and targeted therapy
    - - FBC
      - Bloof film
        
        Smear cells