Please enable JavaScript.
Coggle requires JavaScript to display documents.
Systemic Lupus Erythematosus (SLE) - Coggle Diagram
Systemic Lupus Erythematosus (SLE)
Clinical Manifestations
Gastrointestinal
indigestion
nausea
Perfusion & Ventilation
pericarditis
pleuritis
myocarditis
Neurological
cognitive dysfunction
Seizures
neuropathies
Hematological
anemia
leukopenia
lymphopenia
thrombocytopenia
Renal
Lupus nephritis
mild to severe kidney damage
Dermatological
Malar rash (butterfly rash)
Musculoskeletal
Muscle pain
arthralgia
Arthritis
chronic autoimmune disease In which the body mistakenly targets Its own healthy tissues and Induces Inflammation and tissue damage
Failure of self tolerant mechanisms
formation of autoantibodies
T-cells aid In B-cell activation and produce pro-inflammatory cytokines
B-cell hyperactivity
More prevalent In females
Estrogen Is Immune stimulatory
chronic complement system activation by Immune complexes
Multi-System Alterations In Functions
Immune complex deposition and pro-inflammatory cytokine release causes vascular damage and inflammation
cardiovascular disease
Risk of coronary artery disease from coronary vasculitis or atherosclerosis
altered ventilation and perfusion
lupus pneumonitis
pleuritis
shrinking lung syndrome
pulmonary arterial hypertension
pulmonary embolism
Lupus nephritis
chronic kidney damage
hematuria
lower extremity edema
CNS & PNS
headaches
seizures
demyelinating syndrome
ischemic strokes
anemia
reproductive alterations
miscarriages
pre-eclampsia
endocrine dysfunction
hyperthyroidism
Treatment Modalities
GOAL: reduce Immune system activity
Corticosteroids
Immunosuppressants
Methotrexate
Azathioprine
Biologics
B-lymphocyte stimulator Inhibitor
GOAL: prevent organ damage
GOAL: manage symptoms
NSAIDs for chronic joint pain