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Toxoplasma gondii - Coggle Diagram
Toxoplasma gondii
INTRODUCTION
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Definite host - cat
Accidental host or intermediate host - Mammals, Humans
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MORPHOLOGY
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Oocyst
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Development in soil , it becomes sporulated oocyst which contains sporozoites in sporoblast.
It has one spherical structure, it is called sporoblast.
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LIFE CYCLE
ENTERIC CYCLE
After fertilization, the zygote formation, it is excreted in feceus.
In soil , the unsporulated oocyst to sporulated oocyst contains 8 sporozoites.
Bradyzoit infects intestinal region and become tachyzoites, it multiple in enormous number in intestine it undergoes sexual cycle after converted and formation of male and female gametes.
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EXOCENTRIC CYCLE
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Infected by sporulated oocyst contaminated the food or unproperly cooked meats which contains Bradyzoit.
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PATHOGENESIS
Lead to still birth, chorientinitis , Hydrocephalus, Microcephaly.
Abnormality of brain development, psychomotor disturbances, blindness, enlarged spleen and liver, jaundice, poor motor coordination, rash.
In 2nd trimester, less severe complication, birth anomalies to common
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LAB DIAGNOSIS
Sabin - Feldman dye test ( confirmatory test) , Latex agglutination test.
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Serodiagnosis - ELISA , IFAT
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Microscopy - blood, sputum, bone marrow aspirates, Giemsa staining
Others - Animal inoculation, skin test of frenkel
TREATMENT
Other alternative drugs - spiramycin , clindamycin , trimethoprim- sulphmethoxazole.
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Combination of pyramethamine , sulphadiazine or Trisulfapyramidines.
