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Trypanosoma Bruce, Demonstrated by bruse in horses and cattles in 1895,…
Trypanosoma Bruce
Trypanosoma Brucei brucei
Trypanosoma Bruce gambiense
Trypanosoma rhodesiense
Demonstrated by
bruse
in horses and cattles in
1895
LIFE CYCLE
PATHOGENICITY
African tryposomiasis [west African sleeping sickness]
Parasitaemia in blood
Winterbottom's sign
Hepatosplenomegaly
MORPHOLOGY
Only one form that is
trypomastigote
•long slender
•intermediate
••short stumpy
Long slender : 20×3 micrometer- motile
Short stumpy: 10×5 micrometer- non-motile
Trypanosoma brucei
Habitat
:
•Blood
• Reticulated tissue
•Intracellular spaces
•Lymph channels
Metabolic trypomastigotes are transmitted to man bt the bite of tselese fly
Metacyclic trypomastigote in wound
Long slender trypomastigote
Multiply by binary fission
Short slumpy form
Invade blood stream
Short stumpy forms are take up by the tsetse fly during blood meal
Long slender form in midgut
Epimastigite in salivary gland
TREATMENT
Suramin
Pentamidine
Eflonnithine
Organic arsenic melarsoprol
LAB DIAGNOSIS
Wet mount
Staining-giemsa staining
Sample -blood, born marrow
Culture- wingman medium
SERIOLOGICAL
CATT
ELISA
IFA
