Please enable JavaScript.
Coggle requires JavaScript to display documents.
Leishmania donovani, Man and other vertebrate host acquire infection by…
Leishmania donovani
Caused by obligate intracellular protozoa of the genus leishmania
Discovered by:
sir William leishman
and
sir donovan
LIFE CYCLE
Man and other vertebrate host acquire infection by bite of sand fly
Regulation from midgut
Transform from
Promastigote to amastigote
Rupture of parasitized cell
Amastigotes carried in the circulation
Invasion of other reticuloendothelial cells
Amastigote released into blood and body fluids.
Sandfly takes up amastigotes while feeding on infected host
Amastigote transform in to promastigote and reproduce by binary fission
Promastigote migrate to anterior midgut
AMASTIGOTE
PROMASTIGOTE
•2-4 in diameter,
•Single nucleus
•Nucleus-1 micrometer
•Non motile
•Lomg slender form
•15- 25 micro meter in length
1.5-3.5 micrometer in breath
•free flagellum
•motile
PATHOGENISIS
Anemic condition
Lymphadenopathy
Hepartosplenomagaly
Fever
Low hemoglobin
Skin changes
LABORATORY DIAGNOSIS
Blood count
Hemoglobin estimation
Peripheral blood film
Culture- NNN media
IMMUNOLOGICAL
ELISA
PCR
CIE
IFAT
TREATMENT
No specific vaccination
Chemotherapy
Monomycin
Pentamidine
Antimoniate
